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Trends That Matter for Growth Hormone Deficiency Treatments

Posted by Angela Maas on Dec 3, 2020


When the FDA approved Novo Nordisk, Inc.'s Sogroya (somapacitan-beco) for the replacement of growth hormone in adults with growth hormone deficiency on Aug. 28, it became the only long-acting agent on the market, AIS Health reported.

There are seven short-acting growth hormones currently available to treat adults with growth hormone deficiency, all of them branded forms of somatropin. Differences among the products, all of which are self-administered, include the strengths available and the type of device to deliver the treatment. But all of them must be administered daily. Sogroya, which also is self-administered, is the only FDA-approved product with weekly dosing.
Mesfin Tegenu, R.Ph., president of PerformRx, LLC, points out that Sogroya "is a human growth hormone (hGH) analog — an hGH with an added albumin-binding moiety. Up until this point, all hGH products have been a recombinant product, identical copies of hGH (rhGH). The half-life of somapacitan is measured in days (two to three days) while the half-life of rhGH (somatropin) is measured in hours (approximately two-and-a-half hours). The extended half-life of somapacitan allows less frequent (weekly) dosing."

He says that payers typically have prior authorization on somatropin, with "controls including diagnostic and lab values as prerequisites." A prescription from an endocrinologist is also a "common practice."
"Somapacitan is likely to be managed similar to all the other rhGH class of drugs," Tegenu says, adding that "it is reasonable to classify it as a second-line or nonpreferred agent whose use is allowed only after a trial and failure of or other medical reason for not using a preferred daily rhGH."
The graphic below show how treatments for growth hormone deficiency are covered among commercial health plans, health exchange programs, Medicare and Medicaid programs under the pharmacy benefit.
Trends 12032020

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Topics: Industry Trends, Data & Analytics, Payer